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Prince Frederik of Luxembourg Passes Away After Brave Battle with POLG Mitochondrial Disease

It is with profound sorrow that we share the heartbreaking news of the passing of Prince Frederik of Luxembourg, who bravely fought against POLG mitochondrial disease, a rare and incurable genetic disorder. Frederik, who was diagnosed at the age of 14, succumbed to the illness on March 1 in Paris, surrounded by his loving family. His death leaves an immeasurable void in the hearts of those who knew him and admired his resilience.

The royal family of Luxembourg announced the devastating news in a deeply emotional Instagram post. His father, Prince Robert of Luxembourg, shared the following words: “It is with a very heavy heart that my wife and I would like to inform you of the passing of our son, The POLG Foundation Founder and Creative Director, Frederik.” He described how, on February 28, Frederik gathered his family to bid them a final, heartfelt farewell.

“Last Friday, February 28th, on ‘Rare Disease Day,’ our beloved son called us into his room to speak to him for one last time. Frederik found the strength and the courage to say goodbye to each of us in turn… He had already spoken all that was in his heart to his extraordinary mother, who had not left his side in 15 years,” Prince Robert wrote, his words heavy with grief and love.

POLG mitochondrial disease is a cruel and relentless condition caused by mutations in the POLG gene. It robs the body’s cells of energy, leading to progressive organ dysfunction and failure. The POLG Foundation, which Frederik founded and led with unwavering dedication, describes the disease as akin to a “faulty battery that never fully recharges and is in a constant state of depletion.”

The disease is exceedingly rare, with no clear estimate of how many individuals it affects. Its symptoms vary widely, ranging from mild to severe, and often include ophthalmoplegia (paralysis of the eye muscles), muscle weakness, epilepsy, and liver failure. The complexity and unpredictability of the disease make it incredibly difficult to treat, and there is currently no cure.

Frederik’s life was a testament to courage and determination. Despite the immense challenges he faced, he channeled his energy into raising awareness about POLG mitochondrial disease and supporting others affected by it. Through the POLG Foundation, he became a beacon of hope for countless families grappling with the devastating impact of this rare condition.

As we mourn the loss of Prince Frederik, we also celebrate his extraordinary spirit and the legacy he leaves behind. His strength, compassion, and unwavering resolve in the face of adversity will continue to inspire all who knew him and those who followed his journey.

Our deepest condolences go to the royal family of Luxembourg, who have lost a beloved son, brother, and advocate. May Frederik’s memory be a source of comfort and strength during this unimaginably difficult time. Rest in peace, dear Frederik. Your light will never fade.